Bone matrix to growth factors: location, location, location

The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)–β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cel...

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Detalles Bibliográficos
Autores principales: Rifkin, Daniel B., Todorovic, Vesna
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101590/
https://www.ncbi.nlm.nih.gov/pubmed/20855500
http://dx.doi.org/10.1083/jcb.201008116
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author Rifkin, Daniel B.
Todorovic, Vesna
author_facet Rifkin, Daniel B.
Todorovic, Vesna
author_sort Rifkin, Daniel B.
collection PubMed
description The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)–β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation.
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spelling pubmed-31015902011-06-06 Bone matrix to growth factors: location, location, location Rifkin, Daniel B. Todorovic, Vesna J Cell Biol Reviews The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)–β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation. The Rockefeller University Press 2010-09-20 /pmc/articles/PMC3101590/ /pubmed/20855500 http://dx.doi.org/10.1083/jcb.201008116 Text en © 2010 Rifkin and Todorovic This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Rifkin, Daniel B.
Todorovic, Vesna
Bone matrix to growth factors: location, location, location
title Bone matrix to growth factors: location, location, location
title_full Bone matrix to growth factors: location, location, location
title_fullStr Bone matrix to growth factors: location, location, location
title_full_unstemmed Bone matrix to growth factors: location, location, location
title_short Bone matrix to growth factors: location, location, location
title_sort bone matrix to growth factors: location, location, location
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101590/
https://www.ncbi.nlm.nih.gov/pubmed/20855500
http://dx.doi.org/10.1083/jcb.201008116
work_keys_str_mv AT rifkindanielb bonematrixtogrowthfactorslocationlocationlocation
AT todorovicvesna bonematrixtogrowthfactorslocationlocationlocation

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