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Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8

The molecular details of the biogenesis of double-membraned autophagosomes are poorly understood. We identify the Saccharomyces cerevisiae AAA–adenosine triphosphatase Cdc48 and its substrate-recruiting cofactor Shp1/Ubx1 as novel components needed for autophagosome biogenesis. In mammals, the Cdc48...

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Detalles Bibliográficos
Autores principales:	Krick, Roswitha, Bremer, Sebastian, Welter, Evelyn, Schlotterhose, Petra, Muehe, Yvonne, Eskelinen, Eeva-Liisa, Thumm, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101598/ https://www.ncbi.nlm.nih.gov/pubmed/20855502 http://dx.doi.org/10.1083/jcb.201002075

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