Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)

The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR ((1)H, (13)C) technique and by X-ray diffraction analysi...

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Detalles Bibliográficos
Autores principales: Adamovich, Sergey N, Mirskova, Anna N, Mirskov, Rudolf G, Schilde, Uwe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101646/
https://www.ncbi.nlm.nih.gov/pubmed/21554686
http://dx.doi.org/10.1186/1752-153X-5-23
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author Adamovich, Sergey N
Mirskova, Anna N
Mirskov, Rudolf G
Schilde, Uwe
author_facet Adamovich, Sergey N
Mirskova, Anna N
Mirskov, Rudolf G
Schilde, Uwe
author_sort Adamovich, Sergey N
collection PubMed
description The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR ((1)H, (13)C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found. Immunoactive properties of the title compound have been screened. The compound has the ability to suppress spontaneous and Con A-stimulated cell proliferation in vitro and therefore can be considered as immunodepressant.
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spelling pubmed-31016462011-05-26 Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate) Adamovich, Sergey N Mirskova, Anna N Mirskov, Rudolf G Schilde, Uwe Chem Cent J Preliminary Communication The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR ((1)H, (13)C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found. Immunoactive properties of the title compound have been screened. The compound has the ability to suppress spontaneous and Con A-stimulated cell proliferation in vitro and therefore can be considered as immunodepressant. BioMed Central 2011-05-09 /pmc/articles/PMC3101646/ /pubmed/21554686 http://dx.doi.org/10.1186/1752-153X-5-23 Text en Copyright ©2011 Adamovich et al
spellingShingle Preliminary Communication
Adamovich, Sergey N
Mirskova, Anna N
Mirskov, Rudolf G
Schilde, Uwe
Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title_full Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title_fullStr Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title_full_unstemmed Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title_short Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
title_sort synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101646/
https://www.ncbi.nlm.nih.gov/pubmed/21554686
http://dx.doi.org/10.1186/1752-153X-5-23
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