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A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution compute...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101794/ https://www.ncbi.nlm.nih.gov/pubmed/21637370 http://dx.doi.org/10.1155/2011/806014 |
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author | Hisata, Shu Kimura, Yuichiro Shibata, Naoko Ono, Shuichi Kobayashi, Takao Chiba, Shigeki Ohta, Hiromitsu Nukiwa, Toshihiro Ebina, Masahito |
author_facet | Hisata, Shu Kimura, Yuichiro Shibata, Naoko Ono, Shuichi Kobayashi, Takao Chiba, Shigeki Ohta, Hiromitsu Nukiwa, Toshihiro Ebina, Masahito |
author_sort | Hisata, Shu |
collection | PubMed |
description | Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n = 11) having both biomarkers elevated were compared with the other patients (n = 6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers. |
format | Text |
id | pubmed-3101794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31017942011-06-02 A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography Hisata, Shu Kimura, Yuichiro Shibata, Naoko Ono, Shuichi Kobayashi, Takao Chiba, Shigeki Ohta, Hiromitsu Nukiwa, Toshihiro Ebina, Masahito Pulm Med Clinical Study Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n = 11) having both biomarkers elevated were compared with the other patients (n = 6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers. Hindawi Publishing Corporation 2011 2010-12-28 /pmc/articles/PMC3101794/ /pubmed/21637370 http://dx.doi.org/10.1155/2011/806014 Text en Copyright © 2011 Shu Hisata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Hisata, Shu Kimura, Yuichiro Shibata, Naoko Ono, Shuichi Kobayashi, Takao Chiba, Shigeki Ohta, Hiromitsu Nukiwa, Toshihiro Ebina, Masahito A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title | A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title_full | A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title_fullStr | A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title_full_unstemmed | A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title_short | A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography |
title_sort | normal range of kl-6/muc1 independent of elevated sp-d indicates a better prognosis in the patients with honeycombing on high-resolution computed tomography |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101794/ https://www.ncbi.nlm.nih.gov/pubmed/21637370 http://dx.doi.org/10.1155/2011/806014 |
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