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A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography

Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution compute...

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Autores principales: Hisata, Shu, Kimura, Yuichiro, Shibata, Naoko, Ono, Shuichi, Kobayashi, Takao, Chiba, Shigeki, Ohta, Hiromitsu, Nukiwa, Toshihiro, Ebina, Masahito
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101794/
https://www.ncbi.nlm.nih.gov/pubmed/21637370
http://dx.doi.org/10.1155/2011/806014
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author Hisata, Shu
Kimura, Yuichiro
Shibata, Naoko
Ono, Shuichi
Kobayashi, Takao
Chiba, Shigeki
Ohta, Hiromitsu
Nukiwa, Toshihiro
Ebina, Masahito
author_facet Hisata, Shu
Kimura, Yuichiro
Shibata, Naoko
Ono, Shuichi
Kobayashi, Takao
Chiba, Shigeki
Ohta, Hiromitsu
Nukiwa, Toshihiro
Ebina, Masahito
author_sort Hisata, Shu
collection PubMed
description Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n = 11) having both biomarkers elevated were compared with the other patients (n = 6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers.
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spelling pubmed-31017942011-06-02 A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography Hisata, Shu Kimura, Yuichiro Shibata, Naoko Ono, Shuichi Kobayashi, Takao Chiba, Shigeki Ohta, Hiromitsu Nukiwa, Toshihiro Ebina, Masahito Pulm Med Clinical Study Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n = 11) having both biomarkers elevated were compared with the other patients (n = 6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers. Hindawi Publishing Corporation 2011 2010-12-28 /pmc/articles/PMC3101794/ /pubmed/21637370 http://dx.doi.org/10.1155/2011/806014 Text en Copyright © 2011 Shu Hisata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Hisata, Shu
Kimura, Yuichiro
Shibata, Naoko
Ono, Shuichi
Kobayashi, Takao
Chiba, Shigeki
Ohta, Hiromitsu
Nukiwa, Toshihiro
Ebina, Masahito
A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title_full A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title_fullStr A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title_full_unstemmed A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title_short A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
title_sort normal range of kl-6/muc1 independent of elevated sp-d indicates a better prognosis in the patients with honeycombing on high-resolution computed tomography
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101794/
https://www.ncbi.nlm.nih.gov/pubmed/21637370
http://dx.doi.org/10.1155/2011/806014
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