The role of reactive oxygen species and autophagy in safingol-induced cell death

Safingol is a sphingolipid with promising anticancer potential, which is currently in phase I clinical trial. Yet, the underlying mechanisms of its action remain largely unknown. We reported here that safingol-induced primarily accidental necrotic cell death in MDA-MB-231 and HT-29 cells, as shown b...

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Detalles Bibliográficos
Autores principales: Ling, L-U, Tan, K-B, Lin, H, Chiu, G N C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101809/
https://www.ncbi.nlm.nih.gov/pubmed/21390063
http://dx.doi.org/10.1038/cddis.2011.12

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