Bioassays to Monitor Taspase1 Function for the Identification of Pharmacogenetic Inhibitors

BACKGROUND: Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibi...

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Detalles Bibliográficos
Autores principales: Knauer, Shirley K., Fetz, Verena, Rabenstein, Jens, Friedl, Sandra, Hofmann, Bettina, Sabiani, Samaneh, Schröder, Elisabeth, Kunst, Lena, Proschak, Eugen, Thines, Eckhard, Kindler, Thomas, Schneider, Gisbert, Marschalek, Rolf, Stauber, Roland H., Bier, Carolin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102056/
https://www.ncbi.nlm.nih.gov/pubmed/21647428
http://dx.doi.org/10.1371/journal.pone.0018253

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