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Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2

Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are...

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Autores principales: Chentoufi, Aziz Alami, Gaudreau, Simon, Nguyen, Alex, Sabha, Mahmoud, Amrani, Abdelaziz, ElGhazali, Geyhad
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102343/
https://www.ncbi.nlm.nih.gov/pubmed/21647403
http://dx.doi.org/10.1155/2011/289343
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author Chentoufi, Aziz Alami
Gaudreau, Simon
Nguyen, Alex
Sabha, Mahmoud
Amrani, Abdelaziz
ElGhazali, Geyhad
author_facet Chentoufi, Aziz Alami
Gaudreau, Simon
Nguyen, Alex
Sabha, Mahmoud
Amrani, Abdelaziz
ElGhazali, Geyhad
author_sort Chentoufi, Aziz Alami
collection PubMed
description Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes.
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spelling pubmed-31023432011-06-06 Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 Chentoufi, Aziz Alami Gaudreau, Simon Nguyen, Alex Sabha, Mahmoud Amrani, Abdelaziz ElGhazali, Geyhad Clin Dev Immunol Review Article Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes. Hindawi Publishing Corporation 2011 2011-05-10 /pmc/articles/PMC3102343/ /pubmed/21647403 http://dx.doi.org/10.1155/2011/289343 Text en Copyright © 2011 Aziz Alami Chentoufi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chentoufi, Aziz Alami
Gaudreau, Simon
Nguyen, Alex
Sabha, Mahmoud
Amrani, Abdelaziz
ElGhazali, Geyhad
Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title_full Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title_fullStr Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title_full_unstemmed Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title_short Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
title_sort type i diabetes-associated tolerogenic properties of interleukin-2
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102343/
https://www.ncbi.nlm.nih.gov/pubmed/21647403
http://dx.doi.org/10.1155/2011/289343
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