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Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102343/ https://www.ncbi.nlm.nih.gov/pubmed/21647403 http://dx.doi.org/10.1155/2011/289343 |
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author | Chentoufi, Aziz Alami Gaudreau, Simon Nguyen, Alex Sabha, Mahmoud Amrani, Abdelaziz ElGhazali, Geyhad |
author_facet | Chentoufi, Aziz Alami Gaudreau, Simon Nguyen, Alex Sabha, Mahmoud Amrani, Abdelaziz ElGhazali, Geyhad |
author_sort | Chentoufi, Aziz Alami |
collection | PubMed |
description | Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes. |
format | Text |
id | pubmed-3102343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31023432011-06-06 Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 Chentoufi, Aziz Alami Gaudreau, Simon Nguyen, Alex Sabha, Mahmoud Amrani, Abdelaziz ElGhazali, Geyhad Clin Dev Immunol Review Article Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes. Hindawi Publishing Corporation 2011 2011-05-10 /pmc/articles/PMC3102343/ /pubmed/21647403 http://dx.doi.org/10.1155/2011/289343 Text en Copyright © 2011 Aziz Alami Chentoufi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chentoufi, Aziz Alami Gaudreau, Simon Nguyen, Alex Sabha, Mahmoud Amrani, Abdelaziz ElGhazali, Geyhad Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title_full | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title_fullStr | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title_full_unstemmed | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title_short | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
title_sort | type i diabetes-associated tolerogenic properties of interleukin-2 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102343/ https://www.ncbi.nlm.nih.gov/pubmed/21647403 http://dx.doi.org/10.1155/2011/289343 |
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