Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management

Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high...

Descripción completa

Detalles Bibliográficos
Autores principales: Dada, Rima, Shamsi, Monis Bilal, Venkatesh, Sunderarjan, Gupta, Naramada Prasad, Kumar, Rajeev
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102462/
https://www.ncbi.nlm.nih.gov/pubmed/21245622
_version_ 1782204377805619200
author Dada, Rima
Shamsi, Monis Bilal
Venkatesh, Sunderarjan
Gupta, Naramada Prasad
Kumar, Rajeev
author_facet Dada, Rima
Shamsi, Monis Bilal
Venkatesh, Sunderarjan
Gupta, Naramada Prasad
Kumar, Rajeev
author_sort Dada, Rima
collection PubMed
description Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery.
format Text
id pubmed-3102462
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-31024622011-06-08 Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management Dada, Rima Shamsi, Monis Bilal Venkatesh, Sunderarjan Gupta, Naramada Prasad Kumar, Rajeev Indian J Med Res Original Article Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery. Medknow Publications 2010-12 /pmc/articles/PMC3102462/ /pubmed/21245622 Text en © The Indian Journal of Medical Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dada, Rima
Shamsi, Monis Bilal
Venkatesh, Sunderarjan
Gupta, Naramada Prasad
Kumar, Rajeev
Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title_full Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title_fullStr Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title_full_unstemmed Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title_short Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management
title_sort attenuation of oxidative stress & dna damage in varicocelectomy: implications in infertility management
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102462/
https://www.ncbi.nlm.nih.gov/pubmed/21245622
work_keys_str_mv AT dadarima attenuationofoxidativestressdnadamageinvaricocelectomyimplicationsininfertilitymanagement
AT shamsimonisbilal attenuationofoxidativestressdnadamageinvaricocelectomyimplicationsininfertilitymanagement
AT venkateshsunderarjan attenuationofoxidativestressdnadamageinvaricocelectomyimplicationsininfertilitymanagement
AT guptanaramadaprasad attenuationofoxidativestressdnadamageinvaricocelectomyimplicationsininfertilitymanagement
AT kumarrajeev attenuationofoxidativestressdnadamageinvaricocelectomyimplicationsininfertilitymanagement

Ejemplares similares