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Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired ins...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102610/ https://www.ncbi.nlm.nih.gov/pubmed/21496338 http://dx.doi.org/10.1186/1475-2840-10-34 |
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author | Nakajima, Kei Nemoto, Tohru Muneyuki, Toshitaka Kakei, Masafumi Fuchigami, Hiroshi Munakata, Hiromi |
author_facet | Nakajima, Kei Nemoto, Tohru Muneyuki, Toshitaka Kakei, Masafumi Fuchigami, Hiroshi Munakata, Hiromi |
author_sort | Nakajima, Kei |
collection | PubMed |
description | BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes. RESEARCH DESIGN AND METHODS: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago. RESULTS: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction. CONCLUSIONS: Our results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions. |
format | Text |
id | pubmed-3102610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31026102011-05-27 Low serum amylase in association with metabolic syndrome and diabetes: A community-based study Nakajima, Kei Nemoto, Tohru Muneyuki, Toshitaka Kakei, Masafumi Fuchigami, Hiroshi Munakata, Hiromi Cardiovasc Diabetol Original Investigation BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes. RESEARCH DESIGN AND METHODS: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago. RESULTS: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction. CONCLUSIONS: Our results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions. BioMed Central 2011-04-17 /pmc/articles/PMC3102610/ /pubmed/21496338 http://dx.doi.org/10.1186/1475-2840-10-34 Text en Copyright ©2011 Nakajima et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Investigation Nakajima, Kei Nemoto, Tohru Muneyuki, Toshitaka Kakei, Masafumi Fuchigami, Hiroshi Munakata, Hiromi Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title | Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title_full | Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title_fullStr | Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title_full_unstemmed | Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title_short | Low serum amylase in association with metabolic syndrome and diabetes: A community-based study |
title_sort | low serum amylase in association with metabolic syndrome and diabetes: a community-based study |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102610/ https://www.ncbi.nlm.nih.gov/pubmed/21496338 http://dx.doi.org/10.1186/1475-2840-10-34 |
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