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Low serum amylase in association with metabolic syndrome and diabetes: A community-based study

BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired ins...

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Autores principales: Nakajima, Kei, Nemoto, Tohru, Muneyuki, Toshitaka, Kakei, Masafumi, Fuchigami, Hiroshi, Munakata, Hiromi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102610/
https://www.ncbi.nlm.nih.gov/pubmed/21496338
http://dx.doi.org/10.1186/1475-2840-10-34
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author Nakajima, Kei
Nemoto, Tohru
Muneyuki, Toshitaka
Kakei, Masafumi
Fuchigami, Hiroshi
Munakata, Hiromi
author_facet Nakajima, Kei
Nemoto, Tohru
Muneyuki, Toshitaka
Kakei, Masafumi
Fuchigami, Hiroshi
Munakata, Hiromi
author_sort Nakajima, Kei
collection PubMed
description BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes. RESEARCH DESIGN AND METHODS: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago. RESULTS: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction. CONCLUSIONS: Our results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions.
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spelling pubmed-31026102011-05-27 Low serum amylase in association with metabolic syndrome and diabetes: A community-based study Nakajima, Kei Nemoto, Tohru Muneyuki, Toshitaka Kakei, Masafumi Fuchigami, Hiroshi Munakata, Hiromi Cardiovasc Diabetol Original Investigation BACKGROUND: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes. RESEARCH DESIGN AND METHODS: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago. RESULTS: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction. CONCLUSIONS: Our results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions. BioMed Central 2011-04-17 /pmc/articles/PMC3102610/ /pubmed/21496338 http://dx.doi.org/10.1186/1475-2840-10-34 Text en Copyright ©2011 Nakajima et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Investigation
Nakajima, Kei
Nemoto, Tohru
Muneyuki, Toshitaka
Kakei, Masafumi
Fuchigami, Hiroshi
Munakata, Hiromi
Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title_full Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title_fullStr Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title_full_unstemmed Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title_short Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
title_sort low serum amylase in association with metabolic syndrome and diabetes: a community-based study
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102610/
https://www.ncbi.nlm.nih.gov/pubmed/21496338
http://dx.doi.org/10.1186/1475-2840-10-34
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