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Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression

Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitive dysfunction in depression, we investigated...

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Autores principales: Alalade, Emmanuel, Denny, Kevin, Potter, Guy, Steffens, David, Wang, Lihong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102667/
https://www.ncbi.nlm.nih.gov/pubmed/21637831
http://dx.doi.org/10.1371/journal.pone.0020035
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author Alalade, Emmanuel
Denny, Kevin
Potter, Guy
Steffens, David
Wang, Lihong
author_facet Alalade, Emmanuel
Denny, Kevin
Potter, Guy
Steffens, David
Wang, Lihong
author_sort Alalade, Emmanuel
collection PubMed
description Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitive dysfunction in depression, we investigated the resting-state functional connectivity between cerebellar regions and the cerebral cortex in samples of patients with geriatric depression (n = 11) and healthy controls (n = 18). Seed-based connectivity analyses were conducted using seeds from cerebellum regions previously identified as being involved in the executive, default-mode, affective-limbic, and motor networks. The results revealed that, compared with controls, individuals with depression show reduced functional connectivity between several cerebellum seed regions, specifically those in the executive and affective-limbic networks with the ventromedial prefrontal cortex (vmPFC) and increased functional connectivity between the motor-related cerebellum seed regions with the putamen and motor cortex. We further investigated whether the altered functional connectivity in depressed patients was associated with cognitive function and severity of depression. A positive correlation was found between the Crus II–vmPFC connectivity and performance on the Hopkins Verbal Learning Test-Revised delayed memory recall. Additionally, the vermis–posterior cinglate cortex (PCC) connectivity was positively correlated with depression severity. Our results suggest that cerebellum–vmPFC coupling may be related to cognitive function whereas cerebellum–PCC coupling may be related to emotion processing in geriatric depression.
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spelling pubmed-31026672011-06-02 Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression Alalade, Emmanuel Denny, Kevin Potter, Guy Steffens, David Wang, Lihong PLoS One Research Article Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitive dysfunction in depression, we investigated the resting-state functional connectivity between cerebellar regions and the cerebral cortex in samples of patients with geriatric depression (n = 11) and healthy controls (n = 18). Seed-based connectivity analyses were conducted using seeds from cerebellum regions previously identified as being involved in the executive, default-mode, affective-limbic, and motor networks. The results revealed that, compared with controls, individuals with depression show reduced functional connectivity between several cerebellum seed regions, specifically those in the executive and affective-limbic networks with the ventromedial prefrontal cortex (vmPFC) and increased functional connectivity between the motor-related cerebellum seed regions with the putamen and motor cortex. We further investigated whether the altered functional connectivity in depressed patients was associated with cognitive function and severity of depression. A positive correlation was found between the Crus II–vmPFC connectivity and performance on the Hopkins Verbal Learning Test-Revised delayed memory recall. Additionally, the vermis–posterior cinglate cortex (PCC) connectivity was positively correlated with depression severity. Our results suggest that cerebellum–vmPFC coupling may be related to cognitive function whereas cerebellum–PCC coupling may be related to emotion processing in geriatric depression. Public Library of Science 2011-05-26 /pmc/articles/PMC3102667/ /pubmed/21637831 http://dx.doi.org/10.1371/journal.pone.0020035 Text en Alalade et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Alalade, Emmanuel
Denny, Kevin
Potter, Guy
Steffens, David
Wang, Lihong
Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title_full Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title_fullStr Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title_full_unstemmed Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title_short Altered Cerebellar-Cerebral Functional Connectivity in Geriatric Depression
title_sort altered cerebellar-cerebral functional connectivity in geriatric depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102667/
https://www.ncbi.nlm.nih.gov/pubmed/21637831
http://dx.doi.org/10.1371/journal.pone.0020035
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