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Suboptimal Activation of Antigen-Specific CD4(+) Effector Cells Enables Persistence of M. tuberculosis In Vivo

Adaptive immunity to Mycobacterium tuberculosis controls progressive bacterial growth and disease but does not eradicate infection. Among CD4(+) T cells in the lungs of M. tuberculosis-infected mice, we observed that few produced IFN-γ without ex vivo restimulation. Therefore, we hypothesized that o...

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Detalles Bibliográficos
Autores principales:	Bold, Tyler D., Banaei, Niaz, Wolf, Andrea J., Ernst, Joel D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102708/ https://www.ncbi.nlm.nih.gov/pubmed/21637811 http://dx.doi.org/10.1371/journal.ppat.1002063

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