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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor mediated currents

KCC2 is a neuron-specific K(+)-Cl(−) cotransporter that maintains a low intracellular Cl(−) concentration essential for hyperpolarizing inhibition mediated by GABA(A) receptors. Deficits in KCC2 activity occur in disease states associated with pathophysiological glutamate release. However, the mecha...

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Detalles Bibliográficos
Autores principales:	Lee, Henry H.C., Deeb, Tarek Z., Walker, Joshua A., Davies, Paul A., Moss, Stephen J.
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102766/ https://www.ncbi.nlm.nih.gov/pubmed/21532577 http://dx.doi.org/10.1038/nn.2806

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