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Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome
PURPOSE: The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC). METHODS: Retrospective review of nine patients referred for management of recurrent OHS le...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102844/ https://www.ncbi.nlm.nih.gov/pubmed/21484182 http://dx.doi.org/10.1007/s12348-010-0016-4 |
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author | Hatef, Elham Turkcuoglu, Peykan Ibrahim, Mohamed Sepah, Yasir Shulman, Matthew Heo, Jangwon Lee, Jeong Hee Channa, Roomasa Khwaja, Afsheen Rentiya, Zubir Shah, Syed Mahmood Do, Diana V. Nguyen, Quan Dong |
author_facet | Hatef, Elham Turkcuoglu, Peykan Ibrahim, Mohamed Sepah, Yasir Shulman, Matthew Heo, Jangwon Lee, Jeong Hee Channa, Roomasa Khwaja, Afsheen Rentiya, Zubir Shah, Syed Mahmood Do, Diana V. Nguyen, Quan Dong |
author_sort | Hatef, Elham |
collection | PubMed |
description | PURPOSE: The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC). METHODS: Retrospective review of nine patients referred for management of recurrent OHS lesions. Serology panel was conducted to rule out autoimmune and infectious causes. RESULTS: Clinical examination revealed multiple small, punched-out peripheral chorioretinal scars, and peripapillary atrophy. Histoplasma antigen/antibody was negative in all patients. Fluorescein angiography and optical coherence tomography confirmed active inflammation in five patients. Immunomodulatory therapy (IMT) was initiated to control active inflammation. While on IMT, visual acuity stabilized or improved in three patients with no recurrence of CNV or lesion activities over the follow-up period. CONCLUSIONS: MFC may initially masquerade as OHS. Clinical characteristics of recurrent MFC and absence of histoplasma titer may lead to consideration of IMT and other proper treatments for MFC. |
format | Text |
id | pubmed-3102844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31028442011-07-14 Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome Hatef, Elham Turkcuoglu, Peykan Ibrahim, Mohamed Sepah, Yasir Shulman, Matthew Heo, Jangwon Lee, Jeong Hee Channa, Roomasa Khwaja, Afsheen Rentiya, Zubir Shah, Syed Mahmood Do, Diana V. Nguyen, Quan Dong J Ophthalmic Inflamm Infect Original Research PURPOSE: The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC). METHODS: Retrospective review of nine patients referred for management of recurrent OHS lesions. Serology panel was conducted to rule out autoimmune and infectious causes. RESULTS: Clinical examination revealed multiple small, punched-out peripheral chorioretinal scars, and peripapillary atrophy. Histoplasma antigen/antibody was negative in all patients. Fluorescein angiography and optical coherence tomography confirmed active inflammation in five patients. Immunomodulatory therapy (IMT) was initiated to control active inflammation. While on IMT, visual acuity stabilized or improved in three patients with no recurrence of CNV or lesion activities over the follow-up period. CONCLUSIONS: MFC may initially masquerade as OHS. Clinical characteristics of recurrent MFC and absence of histoplasma titer may lead to consideration of IMT and other proper treatments for MFC. Springer-Verlag 2011-03-16 /pmc/articles/PMC3102844/ /pubmed/21484182 http://dx.doi.org/10.1007/s12348-010-0016-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Research Hatef, Elham Turkcuoglu, Peykan Ibrahim, Mohamed Sepah, Yasir Shulman, Matthew Heo, Jangwon Lee, Jeong Hee Channa, Roomasa Khwaja, Afsheen Rentiya, Zubir Shah, Syed Mahmood Do, Diana V. Nguyen, Quan Dong Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title | Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title_full | Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title_fullStr | Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title_full_unstemmed | Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title_short | Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
title_sort | importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102844/ https://www.ncbi.nlm.nih.gov/pubmed/21484182 http://dx.doi.org/10.1007/s12348-010-0016-4 |
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