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Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years

This study aimed to assess the immune status of the Korean population against hepatitis A virus (HAV). Residual serum samples from 2008 to 2010 were collected from diagnostic laboratories and a total of 1,872 samples were analyzed. Anti-HAV seroprevalence was 57.3% in subjects aged 1-4 yr, 69.8% at...

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Autores principales: Lee, Hyunju, Cho, Hye Kyung, Kim, Jong-Hyun, Kim, Kyung-Hyo
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102874/
https://www.ncbi.nlm.nih.gov/pubmed/21655066
http://dx.doi.org/10.3346/jkms.2011.26.6.791
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author Lee, Hyunju
Cho, Hye Kyung
Kim, Jong-Hyun
Kim, Kyung-Hyo
author_facet Lee, Hyunju
Cho, Hye Kyung
Kim, Jong-Hyun
Kim, Kyung-Hyo
author_sort Lee, Hyunju
collection PubMed
description This study aimed to assess the immune status of the Korean population against hepatitis A virus (HAV). Residual serum samples from 2008 to 2010 were collected from diagnostic laboratories and a total of 1,872 samples were analyzed. Anti-HAV seroprevalence was 57.3% in subjects aged 1-4 yr, 69.8% at 5-9 yr and decreased to 38.8% at 10-14 yr, 13.0% at 15-19 yr, and 11.7% at 20-29 yr. Seroprevalence increased with increasing age: 52.2% at 30-39 yr, 83.2% at 40-49 yr, 81.4% at 50-59 yr, 93.2% at 60-69 yr, and 95.1% at 70-79 yr. The most susceptible age group consisted of subjects aged 10-29 yr, especially those aged 20-29 yr. This pattern is markedly different from that in the past 3 decades, where the most susceptible group had consisted of children aged less than 10 yr and almost all subjects aged more than 20 yr had developed anti-HAV antibodies. Because of improvements in hygiene and introduction of hepatitis A vaccine, the age demographic of the susceptible population has shifted. These data are important for creating new prevention measures, including vaccination policies, to prevent and control outbreaks of hepatitis A in Korea.
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spelling pubmed-31028742011-06-09 Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years Lee, Hyunju Cho, Hye Kyung Kim, Jong-Hyun Kim, Kyung-Hyo J Korean Med Sci Original Article This study aimed to assess the immune status of the Korean population against hepatitis A virus (HAV). Residual serum samples from 2008 to 2010 were collected from diagnostic laboratories and a total of 1,872 samples were analyzed. Anti-HAV seroprevalence was 57.3% in subjects aged 1-4 yr, 69.8% at 5-9 yr and decreased to 38.8% at 10-14 yr, 13.0% at 15-19 yr, and 11.7% at 20-29 yr. Seroprevalence increased with increasing age: 52.2% at 30-39 yr, 83.2% at 40-49 yr, 81.4% at 50-59 yr, 93.2% at 60-69 yr, and 95.1% at 70-79 yr. The most susceptible age group consisted of subjects aged 10-29 yr, especially those aged 20-29 yr. This pattern is markedly different from that in the past 3 decades, where the most susceptible group had consisted of children aged less than 10 yr and almost all subjects aged more than 20 yr had developed anti-HAV antibodies. Because of improvements in hygiene and introduction of hepatitis A vaccine, the age demographic of the susceptible population has shifted. These data are important for creating new prevention measures, including vaccination policies, to prevent and control outbreaks of hepatitis A in Korea. The Korean Academy of Medical Sciences 2011-06 2011-05-18 /pmc/articles/PMC3102874/ /pubmed/21655066 http://dx.doi.org/10.3346/jkms.2011.26.6.791 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Hyunju
Cho, Hye Kyung
Kim, Jong-Hyun
Kim, Kyung-Hyo
Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title_full Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title_fullStr Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title_full_unstemmed Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title_short Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years
title_sort seroepidemiology of hepatitis a in korea: changes over the past 30 years
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102874/
https://www.ncbi.nlm.nih.gov/pubmed/21655066
http://dx.doi.org/10.3346/jkms.2011.26.6.791
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