QTLMAS 2010: simulated dataset

BACKGROUND: Objective was to simulate the data for the QTLMAS 2010 Workshop under a model that includes major additive, epistatic and parent-of-origin effects. RESULTS: Data were simulated for 3226 individuals in 5 generations. Genomic data for 5 chromosomes were simulated using coalescent model. In total, the data included 10,031 SNPs, 30 additive QTLs, 2 interacting QTL pairs, and 3 imprinted loci. The density was 20 SNPs/1Mb, whereas mean linkage disequilibrium between adjacent SNPs was 0.1. One quantitative and one binary trait were simulated with heritability of 0.39-0.52 and additive correlation of 0.59. The data can be used as a benchmark for comparison of QTL mapping methods and models for genomic breeding value estimation under complex genetic architecture.