Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast

Pathological neuronal inclusions of the 43-kDa TAR DNA-binding protein (TDP-43) are implicated in dementia and motor neuron disorders; however, the molecular mechanisms of the underlying cell loss remain poorly understood. Here we used a yeast model to elucidate cell death mechanisms upon expression...

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Detalles Bibliográficos
Autores principales: Braun, Ralf J., Sommer, Cornelia, Carmona-Gutierrez, Didac, Khoury, Chamel M., Ring, Julia, Büttner, Sabrina, Madeo, Frank
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103370/
https://www.ncbi.nlm.nih.gov/pubmed/21471218
http://dx.doi.org/10.1074/jbc.M110.194852

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