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Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP

We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degradation of p53 through ubiquitin-proteasome degradation. JNJ-26854165 and RO5045337 are 2 s...

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Detalles Bibliográficos
Autores principales:	Yuan, Yuan, Liao, Yu-Min, Hsueh, Chung-Tsen, Mirshahidi, Hamid R
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103487/ https://www.ncbi.nlm.nih.gov/pubmed/21504625 http://dx.doi.org/10.1186/1756-8722-4-16

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