Mammalian Sirt1: insights on its biological functions

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-ass...

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Detalles Bibliográficos
Autores principales: Rahman, Shahedur, Islam, Rezuanul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103488/
https://www.ncbi.nlm.nih.gov/pubmed/21549004
http://dx.doi.org/10.1186/1478-811X-9-11
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author Rahman, Shahedur
Islam, Rezuanul
author_facet Rahman, Shahedur
Islam, Rezuanul
author_sort Rahman, Shahedur
collection PubMed
description Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.
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spelling pubmed-31034882011-05-28 Mammalian Sirt1: insights on its biological functions Rahman, Shahedur Islam, Rezuanul Cell Commun Signal Review Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival. BioMed Central 2011-05-08 /pmc/articles/PMC3103488/ /pubmed/21549004 http://dx.doi.org/10.1186/1478-811X-9-11 Text en Copyright ©2011 Rahman and Islam; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rahman, Shahedur
Islam, Rezuanul
Mammalian Sirt1: insights on its biological functions
title Mammalian Sirt1: insights on its biological functions
title_full Mammalian Sirt1: insights on its biological functions
title_fullStr Mammalian Sirt1: insights on its biological functions
title_full_unstemmed Mammalian Sirt1: insights on its biological functions
title_short Mammalian Sirt1: insights on its biological functions
title_sort mammalian sirt1: insights on its biological functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103488/
https://www.ncbi.nlm.nih.gov/pubmed/21549004
http://dx.doi.org/10.1186/1478-811X-9-11
work_keys_str_mv AT rahmanshahedur mammaliansirt1insightsonitsbiologicalfunctions
AT islamrezuanul mammaliansirt1insightsonitsbiologicalfunctions

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