Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associate with risk. Associations with sEOC among...

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Autores principales: Amankwah, Ernest K., Wang, Qinggang, Schildkraut, Joellen M., Tsai, Ya-Yu, Ramus, Susan J., Fridley, Brooke L., Beesley, Jonathan, Johnatty, Sharon E., Webb, Penelope M., Chenevix-Trench, Georgia, Dale, Laura C., Lambrechts, Diether, Amant, Frederic, Despierre, Evelyn, Vergote, Ignace, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Menon, Usha, Chang-Claude, Jenny, Wang-Gohrke, Shan, Anton-Culver, Hoda, Ziogas, Argyrios, Dörk, Thilo, Dürst, Matthias, Antonenkova, Natalia, Bogdanova, Natalia, Brown, Robert, Flanagan, James M., Kaye, Stanley B., Paul, James, Bützow, Ralf, Nevanlinna, Heli, Campbell, Ian, Eccles, Diana M., Karlan, Beth Y., Gross, Jenny, Walsh, Christine, Pharoah, Paul D. P., Song, Honglin, Krüger Kjær, Susanne, Høgdall, Estrid, Høgdall, Claus, Lundvall, Lene, Nedergaard, Lotte, Kiemeney, Lambertus A. L. M., Massuger, Leon F. A. G., van Altena, Anne M., Vermeulen, Sita H. H. M., Le, Nhu D., Brooks-Wilson, Angela, Cook, Linda S., Phelan, Catherine M., Cunningham, Julie M., Vachon, Celine M., Vierkant, Robert A., Iversen, Edwin S., Berchuck, Andrew, Goode, Ellen L., Sellers, Thomas A., Kelemen, Linda E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103497/
https://www.ncbi.nlm.nih.gov/pubmed/21637745
http://dx.doi.org/10.1371/journal.pone.0019642

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