Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients

Norwalk virus and human papilloma virus, two viruses that infect humans at mucosal surfaces, have been found capable of rapidly penetrating human mucus secretions. Viral vectors for gene therapy of Cystic Fibrosis (CF) must similarly penetrate purulent lung airway mucus (sputum) to deliver DNA to ai...

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Detalles Bibliográficos
Autores principales: Hida, Kaoru, Lai, Samuel K., Suk, Jung Soo, Won, Sang Y., Boyle, Michael P., Hanes, Justin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103503/
https://www.ncbi.nlm.nih.gov/pubmed/21637751
http://dx.doi.org/10.1371/journal.pone.0019919

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