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Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort

OBJECTIVE: Infancy is a critical period during which rapid growth potentially programs future disease risk. Identifying the modifiable determinants of growth is therefore important. To capture the complexity of infant growth, we modeled growth trajectories from birth to six months in order to compar...

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Autores principales: Johnson, Laura, Llewellyn, Clare H., van Jaarsveld, Cornelia H. M., Cole, Tim J., Wardle, Jane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103521/
https://www.ncbi.nlm.nih.gov/pubmed/21637764
http://dx.doi.org/10.1371/journal.pone.0019918
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author Johnson, Laura
Llewellyn, Clare H.
van Jaarsveld, Cornelia H. M.
Cole, Tim J.
Wardle, Jane
author_facet Johnson, Laura
Llewellyn, Clare H.
van Jaarsveld, Cornelia H. M.
Cole, Tim J.
Wardle, Jane
author_sort Johnson, Laura
collection PubMed
description OBJECTIVE: Infancy is a critical period during which rapid growth potentially programs future disease risk. Identifying the modifiable determinants of growth is therefore important. To capture the complexity of infant growth, we modeled growth trajectories from birth to six months in order to compare the genetic and environmental influences on growth trajectory parameters with single time-point measures at birth, three and six months of age. METHODS: Data were from Gemini, a population sample of 2402 UK families with twins. An average 10 weight measurements per child made by health professionals were available over the first six months. Weights at birth, three and six months were identified. Longitudinal growth trajectories were modeled using SITAR utilizing all available weight measures for each child. SITAR generates three parameters: size (characterizing mean weight throughout infancy), tempo (indicating age at peak weight velocity (PWV)), and velocity (reflecting the size of PWV). Genetic and environmental influences were estimated using quantitative genetic analysis. RESULTS: In line with previous studies, heritability of weight at birth and three months was low (38%), but it was higher at six months (62%). Heritability of the growth trajectory parameters was high for size (69%) and velocity (57%), but low (35%) for tempo. Common environmental influences predominated for tempo (42%). CONCLUSION: Modeled growth parameters using SITAR indicated that size and velocity were primarily under genetic influence but tempo was predominantly environmentally determined. These results emphasize the importance of identifying specific modifiable environmental determinants of the timing of peak infant growth.
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spelling pubmed-31035212011-06-02 Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort Johnson, Laura Llewellyn, Clare H. van Jaarsveld, Cornelia H. M. Cole, Tim J. Wardle, Jane PLoS One Research Article OBJECTIVE: Infancy is a critical period during which rapid growth potentially programs future disease risk. Identifying the modifiable determinants of growth is therefore important. To capture the complexity of infant growth, we modeled growth trajectories from birth to six months in order to compare the genetic and environmental influences on growth trajectory parameters with single time-point measures at birth, three and six months of age. METHODS: Data were from Gemini, a population sample of 2402 UK families with twins. An average 10 weight measurements per child made by health professionals were available over the first six months. Weights at birth, three and six months were identified. Longitudinal growth trajectories were modeled using SITAR utilizing all available weight measures for each child. SITAR generates three parameters: size (characterizing mean weight throughout infancy), tempo (indicating age at peak weight velocity (PWV)), and velocity (reflecting the size of PWV). Genetic and environmental influences were estimated using quantitative genetic analysis. RESULTS: In line with previous studies, heritability of weight at birth and three months was low (38%), but it was higher at six months (62%). Heritability of the growth trajectory parameters was high for size (69%) and velocity (57%), but low (35%) for tempo. Common environmental influences predominated for tempo (42%). CONCLUSION: Modeled growth parameters using SITAR indicated that size and velocity were primarily under genetic influence but tempo was predominantly environmentally determined. These results emphasize the importance of identifying specific modifiable environmental determinants of the timing of peak infant growth. Public Library of Science 2011-05-27 /pmc/articles/PMC3103521/ /pubmed/21637764 http://dx.doi.org/10.1371/journal.pone.0019918 Text en Johnson et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Johnson, Laura
Llewellyn, Clare H.
van Jaarsveld, Cornelia H. M.
Cole, Tim J.
Wardle, Jane
Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title_full Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title_fullStr Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title_full_unstemmed Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title_short Genetic and Environmental Influences on Infant Growth: Prospective Analysis of the Gemini Twin Birth Cohort
title_sort genetic and environmental influences on infant growth: prospective analysis of the gemini twin birth cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103521/
https://www.ncbi.nlm.nih.gov/pubmed/21637764
http://dx.doi.org/10.1371/journal.pone.0019918
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