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Tenofovir Renal Proximal Tubular Toxicity Is Regulated By OAT1 and MRP4 Transporters

Tenofovir disoproxil fumarate (TDF) is an oral prodrug and acyclic nucleotide analog of adenosine monophosphate that inhibits HIV-1 (HIV) reverse transcriptase. A growing subset of TDF-treated HIV(+) individuals presented with acute renal failure, suggesting tenofovir-associated kidney-specific toxi...

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Detalles Bibliográficos
Autores principales:	Kohler, James J., Hosseini, Seyed H., Green, Elgin, Abuin, Allison, Ludaway, Tomika, Russ, Rodney, Santoianni, Robert, Lewis, William
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103636/ https://www.ncbi.nlm.nih.gov/pubmed/21403643 http://dx.doi.org/10.1038/labinvest.2011.48

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