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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion cells and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It rema...

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Autores principales: Johnson, Stuart L., Eckrich, Tobias, Kuhn, Stephanie, Zampini, Valeria, Franz, Christoph, Ranatunga, Kishani M., Roberts, Terri P., Masetto, Sergio, Knipper, Marlies, Kros, Corné J., Marcotti, Walter
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103712/
https://www.ncbi.nlm.nih.gov/pubmed/21572434
http://dx.doi.org/10.1038/nn.2803
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author Johnson, Stuart L.
Eckrich, Tobias
Kuhn, Stephanie
Zampini, Valeria
Franz, Christoph
Ranatunga, Kishani M.
Roberts, Terri P.
Masetto, Sergio
Knipper, Marlies
Kros, Corné J.
Marcotti, Walter
author_facet Johnson, Stuart L.
Eckrich, Tobias
Kuhn, Stephanie
Zampini, Valeria
Franz, Christoph
Ranatunga, Kishani M.
Roberts, Terri P.
Masetto, Sergio
Knipper, Marlies
Kros, Corné J.
Marcotti, Walter
author_sort Johnson, Stuart L.
collection PubMed
description Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion cells and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials are intrinsically generated by immature IHCs of altricial rodents and that apical IHCs exhibit bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter ACh, by fine-tuning the IHC’s resting membrane potential (V(m)), is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the V(m) of apical and basal IHCs by activating SK2 channels. We hypothesize that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway.
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spelling pubmed-31037122011-12-01 Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells Johnson, Stuart L. Eckrich, Tobias Kuhn, Stephanie Zampini, Valeria Franz, Christoph Ranatunga, Kishani M. Roberts, Terri P. Masetto, Sergio Knipper, Marlies Kros, Corné J. Marcotti, Walter Nat Neurosci Article Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion cells and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials are intrinsically generated by immature IHCs of altricial rodents and that apical IHCs exhibit bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter ACh, by fine-tuning the IHC’s resting membrane potential (V(m)), is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the V(m) of apical and basal IHCs by activating SK2 channels. We hypothesize that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway. 2011-05-15 2011-06 /pmc/articles/PMC3103712/ /pubmed/21572434 http://dx.doi.org/10.1038/nn.2803 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Johnson, Stuart L.
Eckrich, Tobias
Kuhn, Stephanie
Zampini, Valeria
Franz, Christoph
Ranatunga, Kishani M.
Roberts, Terri P.
Masetto, Sergio
Knipper, Marlies
Kros, Corné J.
Marcotti, Walter
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title_full Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title_fullStr Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title_full_unstemmed Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title_short Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
title_sort position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103712/
https://www.ncbi.nlm.nih.gov/pubmed/21572434
http://dx.doi.org/10.1038/nn.2803
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