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Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department

Procalcitonin (PCT) has been shown to be of additional value in the work-up of a febrile patient. This study is the first to investigate the additional value of PCT in an Afro-Caribbean febrile population at the emergency department (ED) of a general hospital. Febrile patients were included at the E...

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Autores principales: Limper, M., de Kruif, M. D., Ajubi, N. E., van Zanten, A. P., Brandjes, D. P. M., Duits, A. J., van Gorp, E. C. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104135/
https://www.ncbi.nlm.nih.gov/pubmed/21594556
http://dx.doi.org/10.1007/s10096-010-1150-5
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author Limper, M.
de Kruif, M. D.
Ajubi, N. E.
van Zanten, A. P.
Brandjes, D. P. M.
Duits, A. J.
van Gorp, E. C. M.
author_facet Limper, M.
de Kruif, M. D.
Ajubi, N. E.
van Zanten, A. P.
Brandjes, D. P. M.
Duits, A. J.
van Gorp, E. C. M.
author_sort Limper, M.
collection PubMed
description Procalcitonin (PCT) has been shown to be of additional value in the work-up of a febrile patient. This study is the first to investigate the additional value of PCT in an Afro-Caribbean febrile population at the emergency department (ED) of a general hospital. Febrile patients were included at the ED. Prospective, blinded PCT measurements were performed in patients with a microbiologically or serologically confirmed diagnosis or a strongly suspected diagnosis on clinical grounds. PCT analysis was performed in 93 patients. PCT levels differentiated well between confirmed bacterial and confirmed viral infection (area under the curve [AUC] of 0.82, sensitivity 85%, specificity 69%, cut-off 0.24 ng/mL), between confirmed bacterial infection and non-infectious fever (AUC of 0.84, sensitivity 90%, specificity 71%, cut-off 0.21 ng/mL) and between all bacterial infections (confirmed and suspected) and non-infectious fever (AUC of 0.80, sensitivity 85%, specificity 71%, cut-off 0.21 ng/mL). C-reactive protein (CRP) levels were shown to be less accurate when comparing the same groups. This is the first study showing that, in a non-Caucasian febrile population at the ED, PCT is a more valuable marker of bacterial infection than CRP. These results may improve diagnostics and eventually decrease antibiotic prescriptions in resource-limited settings.
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spelling pubmed-31041352011-07-14 Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department Limper, M. de Kruif, M. D. Ajubi, N. E. van Zanten, A. P. Brandjes, D. P. M. Duits, A. J. van Gorp, E. C. M. Eur J Clin Microbiol Infect Dis Article Procalcitonin (PCT) has been shown to be of additional value in the work-up of a febrile patient. This study is the first to investigate the additional value of PCT in an Afro-Caribbean febrile population at the emergency department (ED) of a general hospital. Febrile patients were included at the ED. Prospective, blinded PCT measurements were performed in patients with a microbiologically or serologically confirmed diagnosis or a strongly suspected diagnosis on clinical grounds. PCT analysis was performed in 93 patients. PCT levels differentiated well between confirmed bacterial and confirmed viral infection (area under the curve [AUC] of 0.82, sensitivity 85%, specificity 69%, cut-off 0.24 ng/mL), between confirmed bacterial infection and non-infectious fever (AUC of 0.84, sensitivity 90%, specificity 71%, cut-off 0.21 ng/mL) and between all bacterial infections (confirmed and suspected) and non-infectious fever (AUC of 0.80, sensitivity 85%, specificity 71%, cut-off 0.21 ng/mL). C-reactive protein (CRP) levels were shown to be less accurate when comparing the same groups. This is the first study showing that, in a non-Caucasian febrile population at the ED, PCT is a more valuable marker of bacterial infection than CRP. These results may improve diagnostics and eventually decrease antibiotic prescriptions in resource-limited settings. Springer-Verlag 2011-05-19 2011 /pmc/articles/PMC3104135/ /pubmed/21594556 http://dx.doi.org/10.1007/s10096-010-1150-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Limper, M.
de Kruif, M. D.
Ajubi, N. E.
van Zanten, A. P.
Brandjes, D. P. M.
Duits, A. J.
van Gorp, E. C. M.
Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title_full Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title_fullStr Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title_full_unstemmed Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title_short Procalcitonin as a potent marker of bacterial infection in febrile Afro-Caribbean patients at the emergency department
title_sort procalcitonin as a potent marker of bacterial infection in febrile afro-caribbean patients at the emergency department
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104135/
https://www.ncbi.nlm.nih.gov/pubmed/21594556
http://dx.doi.org/10.1007/s10096-010-1150-5
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