Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115

We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs...

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Detalles Bibliográficos
Autores principales: Ko, Eun-Ju, Byon, Yun-Young, Jee, Youngheun, Shin, Taekyun, Park, Seung-Chun, Hahn, Tae-Wook, Joo, Hong-Gu
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104174/
https://www.ncbi.nlm.nih.gov/pubmed/21586879
http://dx.doi.org/10.4142/jvs.2011.12.2.187
Descripción
Sumario:We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.

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