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The protective effect of Malva sylvestris on rat kidney damaged by vanadium

BACKGROUND: The protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an al...

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Autores principales: Marouane, Wafa, Soussi, Ahlem, Murat, Jean-Claude, Bezzine, Sofiane, El Feki, Abdelfattah
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104358/
https://www.ncbi.nlm.nih.gov/pubmed/21513564
http://dx.doi.org/10.1186/1476-511X-10-65
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author Marouane, Wafa
Soussi, Ahlem
Murat, Jean-Claude
Bezzine, Sofiane
El Feki, Abdelfattah
author_facet Marouane, Wafa
Soussi, Ahlem
Murat, Jean-Claude
Bezzine, Sofiane
El Feki, Abdelfattah
author_sort Marouane, Wafa
collection PubMed
description BACKGROUND: The protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay. RESULTS: In 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats. CONCLUSION: Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.
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spelling pubmed-31043582011-06-01 The protective effect of Malva sylvestris on rat kidney damaged by vanadium Marouane, Wafa Soussi, Ahlem Murat, Jean-Claude Bezzine, Sofiane El Feki, Abdelfattah Lipids Health Dis Research BACKGROUND: The protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay. RESULTS: In 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats. CONCLUSION: Malva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds. BioMed Central 2011-04-23 /pmc/articles/PMC3104358/ /pubmed/21513564 http://dx.doi.org/10.1186/1476-511X-10-65 Text en Copyright ©2011 Marouane et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Marouane, Wafa
Soussi, Ahlem
Murat, Jean-Claude
Bezzine, Sofiane
El Feki, Abdelfattah
The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title_full The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title_fullStr The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title_full_unstemmed The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title_short The protective effect of Malva sylvestris on rat kidney damaged by vanadium
title_sort protective effect of malva sylvestris on rat kidney damaged by vanadium
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104358/
https://www.ncbi.nlm.nih.gov/pubmed/21513564
http://dx.doi.org/10.1186/1476-511X-10-65
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