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N-acetylcysteine lacks universal inhibitory activity against influenza A viruses

N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication in vitro and to attenuate the severity of the disease in mouse models. Although available studies were ma...

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Autores principales: Garigliany, Mutien-Marie O, Desmecht, Daniel J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104374/
https://www.ncbi.nlm.nih.gov/pubmed/21554703
http://dx.doi.org/10.1186/1477-5751-10-5
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author Garigliany, Mutien-Marie O
Desmecht, Daniel J
author_facet Garigliany, Mutien-Marie O
Desmecht, Daniel J
author_sort Garigliany, Mutien-Marie O
collection PubMed
description N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication in vitro and to attenuate the severity of the disease in mouse models. Although available studies were made with different viruses (human and avian), published information related to the anti-influenza spectrum of NAC is scarce. In this study, we show that NAC is unable to alter the course of a fatal influenza pneumonia caused by inoculation of a murinized swine H1N1 influenza virus. NAC was indeed able to inhibit the swine virus in vitro but far less than reported for other strains. Therefore, susceptibility of influenza viruses to NAC appears to be strain-dependent, suggesting that it cannot be considered as a universal treatment for influenza pneumonia.
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spelling pubmed-31043742011-06-01 N-acetylcysteine lacks universal inhibitory activity against influenza A viruses Garigliany, Mutien-Marie O Desmecht, Daniel J J Negat Results Biomed Brief Report N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication in vitro and to attenuate the severity of the disease in mouse models. Although available studies were made with different viruses (human and avian), published information related to the anti-influenza spectrum of NAC is scarce. In this study, we show that NAC is unable to alter the course of a fatal influenza pneumonia caused by inoculation of a murinized swine H1N1 influenza virus. NAC was indeed able to inhibit the swine virus in vitro but far less than reported for other strains. Therefore, susceptibility of influenza viruses to NAC appears to be strain-dependent, suggesting that it cannot be considered as a universal treatment for influenza pneumonia. BioMed Central 2011-05-09 /pmc/articles/PMC3104374/ /pubmed/21554703 http://dx.doi.org/10.1186/1477-5751-10-5 Text en Copyright ©2011 Garigliany and Desmecht; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Garigliany, Mutien-Marie O
Desmecht, Daniel J
N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title_full N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title_fullStr N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title_full_unstemmed N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title_short N-acetylcysteine lacks universal inhibitory activity against influenza A viruses
title_sort n-acetylcysteine lacks universal inhibitory activity against influenza a viruses
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104374/
https://www.ncbi.nlm.nih.gov/pubmed/21554703
http://dx.doi.org/10.1186/1477-5751-10-5
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