The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4(+) T cells

Regulatory T cells (Tregs) have a central role in maintaining immune homoeostasis through various mechanisms. Although the Forkhead transcription factor Foxp3 defines the Treg cell lineage and functions, the molecular mechanisms of Foxp3 induction and maintenance remain elusive. Here we show that Fo...

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Detalles Bibliográficos
Autores principales: Sekiya, Takashi, Kashiwagi, Ikkou, Inoue, Naoko, Morita, Rimpei, Hori, Shohei, Waldmann, Herman, Rudensky, Alexander Y., Ichinose, Hiroshi, Metzger, Daniel, Chambon, Pierre, Yoshimura, Akihiko
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104557/
https://www.ncbi.nlm.nih.gov/pubmed/21468021
http://dx.doi.org/10.1038/ncomms1272

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