Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome

We describe a 50-year-old Japanese patient with dermatofibrosarcoma protuberans (DFSP) rapidly growing after bilateral adrenalectomy for Cushing's syndrome that reduced the serum level of cortisol from 17.1 to 0.8 mg/dl. It is known that glucocorticoids decrease the transcriptions of the COL1A1...

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Autores principales: Furudate, Sadanori, Fujimura, Taku, Hashimoto, Akira, Aiba, Setsuya
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Published: May 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104867/
https://www.ncbi.nlm.nih.gov/pubmed/21677889
http://dx.doi.org/10.1159/000329000
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author Furudate, Sadanori
Fujimura, Taku
Hashimoto, Akira
Aiba, Setsuya
author_facet Furudate, Sadanori
Fujimura, Taku
Hashimoto, Akira
Aiba, Setsuya
author_sort Furudate, Sadanori
collection PubMed
description We describe a 50-year-old Japanese patient with dermatofibrosarcoma protuberans (DFSP) rapidly growing after bilateral adrenalectomy for Cushing's syndrome that reduced the serum level of cortisol from 17.1 to 0.8 mg/dl. It is known that glucocorticoids decrease the transcriptions of the COL1A1 gene and the PDGFB gene, which is under the direct control of the COL1A1 gene in most DFSP. Therefore, the hypersecretion of glucocorticoids in Cushing's syndrome might suppress the development of DFSP. To the best of our knowledge, this is the first case of rapid growth of DFSP that may be associated with bilateral adrenalectomy for Cushing's syndrome.
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spelling pubmed-31048672011-06-14 Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome Furudate, Sadanori Fujimura, Taku Hashimoto, Akira Aiba, Setsuya Case Rep Dermatol Published: May 2011 We describe a 50-year-old Japanese patient with dermatofibrosarcoma protuberans (DFSP) rapidly growing after bilateral adrenalectomy for Cushing's syndrome that reduced the serum level of cortisol from 17.1 to 0.8 mg/dl. It is known that glucocorticoids decrease the transcriptions of the COL1A1 gene and the PDGFB gene, which is under the direct control of the COL1A1 gene in most DFSP. Therefore, the hypersecretion of glucocorticoids in Cushing's syndrome might suppress the development of DFSP. To the best of our knowledge, this is the first case of rapid growth of DFSP that may be associated with bilateral adrenalectomy for Cushing's syndrome. S. Karger AG 2011-05-20 /pmc/articles/PMC3104867/ /pubmed/21677889 http://dx.doi.org/10.1159/000329000 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: May 2011
Furudate, Sadanori
Fujimura, Taku
Hashimoto, Akira
Aiba, Setsuya
Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title_full Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title_fullStr Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title_full_unstemmed Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title_short Rapid Growth of Dermatofibrosarcoma Protuberans Associated with Bilateral Adrenalectomy for Cushing's Syndrome
title_sort rapid growth of dermatofibrosarcoma protuberans associated with bilateral adrenalectomy for cushing's syndrome
topic Published: May 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104867/
https://www.ncbi.nlm.nih.gov/pubmed/21677889
http://dx.doi.org/10.1159/000329000
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