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Oct4-Induced Reprogramming Is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons

Neural stem cells (NSCs) lose their competency to generate region-specific neuronal populations at an early stage during embryonic brain development. Here we investigated whether epigenetic modifications can reverse the regional restriction of mouse adult brain subventricular zone (SVZ) NSCs. Using...

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Detalles Bibliográficos
Autores principales:	Deleidi, Michela, Cooper, Oliver, Hargus, Gunnar, Levy, Adam, Isacson, Ole
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104995/ https://www.ncbi.nlm.nih.gov/pubmed/21655272 http://dx.doi.org/10.1371/journal.pone.0019926

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