Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)(SL) Mice

BACKGROUND: NADPH oxidase is implicated in neurotoxic microglial activation and the progressive nature of Alzheimer's Disease (AD). Here, we test the ability of two NADPH oxidase inhibitors, apocynin and dextromethorphan (DM), to reduce learning deficits and neuropathology in transgenic mice ov...

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Detalles Bibliográficos
Autores principales: Lull, Melinda E., Levesque, Shannon, Surace, Michael J., Block, Michelle L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105011/
https://www.ncbi.nlm.nih.gov/pubmed/21655287
http://dx.doi.org/10.1371/journal.pone.0020153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105011/
https://www.ncbi.nlm.nih.gov/pubmed/21655287
http://dx.doi.org/10.1371/journal.pone.0020153

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