Cargando…

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)(SL) Mice

BACKGROUND: NADPH oxidase is implicated in neurotoxic microglial activation and the progressive nature of Alzheimer's Disease (AD). Here, we test the ability of two NADPH oxidase inhibitors, apocynin and dextromethorphan (DM), to reduce learning deficits and neuropathology in transgenic mice ov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lull, Melinda E., Levesque, Shannon, Surace, Michael J., Block, Michelle L.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105011/ https://www.ncbi.nlm.nih.gov/pubmed/21655287 http://dx.doi.org/10.1371/journal.pone.0020153

Ejemplares similares

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
por: Steffen, Johannes, et al.
Publicado: (2017)

Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
por: Ammassari-Teule, Martine
Publicado: (2020)

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Wright, Amanda L., et al.
Publicado: (2013)

Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load
por: Oroszi, Tamas, et al.
Publicado: (2023)

Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat
por: Levit, Alexander, et al.
Publicado: (2020)

The HAPPE plus Event-Related (HAPPE+ER) software: A standardized preprocessing pipeline for event-related potential analyses
por: Monachino, A.D., et al.
Publicado: (2022)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

Improvement of Pharmacokinetics Behavior of Apocynin by Nitrone Derivatization: Comparative Pharmacokinetics of Nitrone-Apocynin and its Parent Apocynin in Rats
por: Wang, Kaiyu, et al.
Publicado: (2013)

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Dhungana, Amolika, et al.
Publicado: (2023)

Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice
por: Lanooij, Suzanne D., et al.
Publicado: (2023)

Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity
por: Levesque, Shannon, et al.
Publicado: (2011)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease
por: Shabir, Osman, et al.
Publicado: (2020)

Delta-secretase triggers Alzheimer’s disease pathologies in wild-type hAPP/hMAPT double transgenic mice
por: Wu, Zhourui, et al.
Publicado: (2020)

Apocynin: Molecular Aptitudes
por: Stefanska, J., et al.
Publicado: (2008)

A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology
por: Lippi, Stephen L. P., et al.
Publicado: (2018)

MD 751: Train Instability Threshold
por: Carver, Lee Robert, et al.
Publicado: (2016)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?
por: Humpel, Christian
Publicado: (2022)

Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice
por: Gulbranson, Daniel R., et al.
Publicado: (2021)

Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain
por: Richards, Danielle, et al.
Publicado: (2014)

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
por: Luo, Ziyi, et al.
Publicado: (2021)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
por: Faizi, Mehrdad, et al.
Publicado: (2012)

HAPPE: A Tool for Population Haplotype Analysis and Visualization in Editable Excel Tables
por: Feng, Cong, et al.
Publicado: (2022)

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
por: Sanchez-Varo, Raquel, et al.
Publicado: (2021)

Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
por: Levesque, Shannon, et al.
Publicado: (2011)

A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease
por: Johnson, Erik C.B., et al.
Publicado: (2016)

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Carney, Rosalind S.E.
Publicado: (2019)

Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
por: Taetzsch, Thomas, et al.
Publicado: (2019)

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation
por: Hajdú, István, et al.
Publicado: (2023)

Microglia use TAM receptors to detect and engulf amyloid beta plaques
por: Huang, Youtong, et al.
Publicado: (2021)

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
por: Fu, Wen, et al.
Publicado: (2017)

HHV-6A infection induces amyloid-beta expression and activation of microglial cells
por: Bortolotti, Daria, et al.
Publicado: (2019)

Gaze patterns and brain activations in humans and marmosets in the Frith-Happé theory-of-mind animation task
por: Dureux, Audrey, et al.
Publicado: (2023)

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
por: Rice, Heather C., et al.
Publicado: (2020)

Clinical and molecular characterization of the R751L-CFTR mutation
por: Haq, Iram J., et al.
Publicado: (2021)

The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review
por: Brand, Abby L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1s2laogtjjlj6fiv430e40sk0t