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The Congenital Cataract-Linked G61C Mutation Destabilizes γD-Crystallin and Promotes Non-Native Aggregation

γD-crystallin is one of the major structural proteins in human eye lens. The solubility and stability of γD-crystallin play a crucial role in maintaining the optical properties of the lens during the life span of an individual. Previous study has shown that the inherited mutation G61C results in aut...

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Detalles Bibliográficos
Autores principales:	Zhang, Wang, Cai, Hong-Chen, Li, Fei-Feng, Xi, Yi-Bo, Ma, Xu, Yan, Yong-Bin
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105094/ https://www.ncbi.nlm.nih.gov/pubmed/21655238 http://dx.doi.org/10.1371/journal.pone.0020564

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