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The Selfish Brain: Stress and Eating Behavior

The brain occupies a special hierarchical position in human energy metabolism. If cerebral homeostasis is threatened, the brain behaves in a “selfish” manner by competing for energy resources with the body. Here we present a logistic approach, which is based on the principles of supply and demand kn...

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Detalles Bibliográficos
Autores principales: Peters, Achim, Kubera, Britta, Hubold, Christian, Langemann, Dirk
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105244/
https://www.ncbi.nlm.nih.gov/pubmed/21660101
http://dx.doi.org/10.3389/fnins.2011.00074
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author Peters, Achim
Kubera, Britta
Hubold, Christian
Langemann, Dirk
author_facet Peters, Achim
Kubera, Britta
Hubold, Christian
Langemann, Dirk
author_sort Peters, Achim
collection PubMed
description The brain occupies a special hierarchical position in human energy metabolism. If cerebral homeostasis is threatened, the brain behaves in a “selfish” manner by competing for energy resources with the body. Here we present a logistic approach, which is based on the principles of supply and demand known from economics. In this “cerebral supply chain” model, the brain constitutes the final consumer. In order to illustrate the operating mode of the cerebral supply chain, we take experimental data which allow assessing the supply, demand and need of the brain under conditions of psychosocial stress. The experimental results show that the brain under conditions of psychosocial stress actively demands energy from the body, in order to cover its increased energy needs. The data demonstrate that the stressed brain uses a mechanism referred to as “cerebral insulin suppression” to limit glucose fluxes into peripheral tissue (muscle, fat) and to enhance cerebral glucose supply. Furthermore psychosocial stress elicits a marked increase in eating behavior in the post-stress phase. Subjects ingested more carbohydrates without any preference for sweet ingredients. These experimentally observed changes of cerebral demand, supply and need are integrated into a logistic framework describing the supply chain of the selfish brain.
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spelling pubmed-31052442011-06-09 The Selfish Brain: Stress and Eating Behavior Peters, Achim Kubera, Britta Hubold, Christian Langemann, Dirk Front Neurosci Neuroscience The brain occupies a special hierarchical position in human energy metabolism. If cerebral homeostasis is threatened, the brain behaves in a “selfish” manner by competing for energy resources with the body. Here we present a logistic approach, which is based on the principles of supply and demand known from economics. In this “cerebral supply chain” model, the brain constitutes the final consumer. In order to illustrate the operating mode of the cerebral supply chain, we take experimental data which allow assessing the supply, demand and need of the brain under conditions of psychosocial stress. The experimental results show that the brain under conditions of psychosocial stress actively demands energy from the body, in order to cover its increased energy needs. The data demonstrate that the stressed brain uses a mechanism referred to as “cerebral insulin suppression” to limit glucose fluxes into peripheral tissue (muscle, fat) and to enhance cerebral glucose supply. Furthermore psychosocial stress elicits a marked increase in eating behavior in the post-stress phase. Subjects ingested more carbohydrates without any preference for sweet ingredients. These experimentally observed changes of cerebral demand, supply and need are integrated into a logistic framework describing the supply chain of the selfish brain. Frontiers Research Foundation 2011-05-30 /pmc/articles/PMC3105244/ /pubmed/21660101 http://dx.doi.org/10.3389/fnins.2011.00074 Text en Copyright © 2011 Peters, Kubera, Hubold and Langemann. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Peters, Achim
Kubera, Britta
Hubold, Christian
Langemann, Dirk
The Selfish Brain: Stress and Eating Behavior
title The Selfish Brain: Stress and Eating Behavior
title_full The Selfish Brain: Stress and Eating Behavior
title_fullStr The Selfish Brain: Stress and Eating Behavior
title_full_unstemmed The Selfish Brain: Stress and Eating Behavior
title_short The Selfish Brain: Stress and Eating Behavior
title_sort selfish brain: stress and eating behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105244/
https://www.ncbi.nlm.nih.gov/pubmed/21660101
http://dx.doi.org/10.3389/fnins.2011.00074
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