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Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope
Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronec...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105298/ https://www.ncbi.nlm.nih.gov/pubmed/21139580 http://dx.doi.org/10.1038/ncomms1135 |