PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

Altered serine protease activity is associated with skin disorders in humans and in mice. The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 family member 8 (Prss8)) is important for epidermal homeostasis and is thus indispensable for postnatal survival in mice,...

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Detalles Bibliográficos
Autores principales: Frateschi, Simona, Camerer, Eric, Crisante, Giovanna, Rieser, Sarah, Membrez, Mathieu, Charles, Roch-Philippe, Beermann, Friedrich, Stehle, Jean-Christophe, Breiden, Bernadette, Sandhoff, Konrad, Rotman, Samuel, Haftek, Marek, Wilson, Anne, Ryser, Stephan, Steinhoff, Martin, Coughlin, Shaun R., Hummler, Edith
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105307/
https://www.ncbi.nlm.nih.gov/pubmed/21245842
http://dx.doi.org/10.1038/ncomms1162

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