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CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responses

The Hedgehog (Hh) morphogen directs distinct cell responses according to its distinct signalling levels. Hh signalling stabilizes transcription factor cubitus interruptus (Ci) by prohibiting SCF(Slimb)-dependent ubiquitylation and proteolysis of Ci. How graded Hh signalling confers differential SCF(...

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Detalles Bibliográficos
Autores principales:	Wu, June-Tai, Lin, Wei-Hsiang, Chen, Wei-Yu, Huang, Yi-Chun, Tang, Chiou-Yang, Ho, Margaret S., Pi, Haiwei, Chien, Cheng-Ting
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105314/ https://www.ncbi.nlm.nih.gov/pubmed/21304511 http://dx.doi.org/10.1038/ncomms1185

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