C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation

The ubiquitin receptors Rad23 and Dsk2 deliver polyubiquitylated substrates to the proteasome for destruction. The C-terminal ubiquitin-associated (UBA) domain of Rad23 functions as a cis-acting stabilization signal that protects this protein from proteasomal degradation. Here, we provide evidence t...

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Detalles Bibliográficos
Autores principales: Heinen, Christian, Ács, Klàra, Hoogstraten, Deborah, Dantuma, Nico P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105319/
https://www.ncbi.nlm.nih.gov/pubmed/21304520
http://dx.doi.org/10.1038/ncomms1179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105319/
https://www.ncbi.nlm.nih.gov/pubmed/21304520
http://dx.doi.org/10.1038/ncomms1179

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