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Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance
Interleukin 10 (IL-10) and regulatory T cells (Tregs) maintain tolerance to intestinal microorganisms. However, Il10(−/−)Rag2(−/−) mice, which lack IL-10 and Tregs, remain healthy, suggesting the existence of other mechanisms of tolerance. Here, we identify suppressor of cytokine signalling 1 (SOCS1...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105338/ https://www.ncbi.nlm.nih.gov/pubmed/21304519 http://dx.doi.org/10.1038/ncomms1181 |
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author | Chinen, Takatoshi Komai, Kyoko Muto, Go Morita, Rimpei Inoue, Naoko Yoshida, Hideyuki Sekiya, Takashi Yoshida, Ryoko Nakamura, Kazuhiko Takayanagi, Ryoichi Yoshimura, Akihiko |
author_facet | Chinen, Takatoshi Komai, Kyoko Muto, Go Morita, Rimpei Inoue, Naoko Yoshida, Hideyuki Sekiya, Takashi Yoshida, Ryoko Nakamura, Kazuhiko Takayanagi, Ryoichi Yoshimura, Akihiko |
author_sort | Chinen, Takatoshi |
collection | PubMed |
description | Interleukin 10 (IL-10) and regulatory T cells (Tregs) maintain tolerance to intestinal microorganisms. However, Il10(−/−)Rag2(−/−) mice, which lack IL-10 and Tregs, remain healthy, suggesting the existence of other mechanisms of tolerance. Here, we identify suppressor of cytokine signalling 1 (SOCS1) as an essential mediator of immune tolerance in the intestine. Socs1(−/−)Rag2(−/−) mice develop severe colitis, which can be prevented by the reduction of microbiota and the transfer of IL-10-sufficient Tregs. Additionally, we find an essential role for prostaglandin E2 (PGE2) in the maintenance of tolerance within the intestine in the absence of Tregs. Socs1(−/−) dendritic cells are resistant to PGE2-mediated immunosuppression because of dysregulated cytokine signalling. Thus, we propose that SOCS1 and PGE2, potentially interacting together, act as an alternative intestinal tolerance mechanism distinct from IL-10 and Tregs. |
format | Text |
id | pubmed-3105338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-31053382011-06-01 Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance Chinen, Takatoshi Komai, Kyoko Muto, Go Morita, Rimpei Inoue, Naoko Yoshida, Hideyuki Sekiya, Takashi Yoshida, Ryoko Nakamura, Kazuhiko Takayanagi, Ryoichi Yoshimura, Akihiko Nat Commun Article Interleukin 10 (IL-10) and regulatory T cells (Tregs) maintain tolerance to intestinal microorganisms. However, Il10(−/−)Rag2(−/−) mice, which lack IL-10 and Tregs, remain healthy, suggesting the existence of other mechanisms of tolerance. Here, we identify suppressor of cytokine signalling 1 (SOCS1) as an essential mediator of immune tolerance in the intestine. Socs1(−/−)Rag2(−/−) mice develop severe colitis, which can be prevented by the reduction of microbiota and the transfer of IL-10-sufficient Tregs. Additionally, we find an essential role for prostaglandin E2 (PGE2) in the maintenance of tolerance within the intestine in the absence of Tregs. Socs1(−/−) dendritic cells are resistant to PGE2-mediated immunosuppression because of dysregulated cytokine signalling. Thus, we propose that SOCS1 and PGE2, potentially interacting together, act as an alternative intestinal tolerance mechanism distinct from IL-10 and Tregs. Nature Publishing Group 2011-02-08 /pmc/articles/PMC3105338/ /pubmed/21304519 http://dx.doi.org/10.1038/ncomms1181 Text en Copyright © 2011, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Chinen, Takatoshi Komai, Kyoko Muto, Go Morita, Rimpei Inoue, Naoko Yoshida, Hideyuki Sekiya, Takashi Yoshida, Ryoko Nakamura, Kazuhiko Takayanagi, Ryoichi Yoshimura, Akihiko Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title | Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title_full | Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title_fullStr | Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title_full_unstemmed | Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title_short | Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance |
title_sort | prostaglandin e2 and socs1 have a role in intestinal immune tolerance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105338/ https://www.ncbi.nlm.nih.gov/pubmed/21304519 http://dx.doi.org/10.1038/ncomms1181 |
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