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Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies
The human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein gp120 presents conserved binding sites for binding to the primary virus receptor CD4 as well as the major HIV chemokine coreceptors, CCR5 and CXCR4. Concerted efforts are underway to understand the specific interactions b...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105500/ https://www.ncbi.nlm.nih.gov/pubmed/21284899 http://dx.doi.org/10.1186/1479-5876-9-S1-S1 |
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author | Tagliamonte, Maria Tornesello, Maria Lina Buonaguro, Franco M Buonaguro, Luigi |
author_facet | Tagliamonte, Maria Tornesello, Maria Lina Buonaguro, Franco M Buonaguro, Luigi |
author_sort | Tagliamonte, Maria |
collection | PubMed |
description | The human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein gp120 presents conserved binding sites for binding to the primary virus receptor CD4 as well as the major HIV chemokine coreceptors, CCR5 and CXCR4. Concerted efforts are underway to understand the specific interactions between gp120 and coreceptors as well as their contribution to the subsequent membrane fusion process. The present review summarizes the current knowledge on this biological aspect, which represents one of the key and essential points of the HIV-host cell interplay and HIV life cycle. The relevance of conformational HIV-1 Envelope proteins presented on Virus-like Particles for appropriate assessment of this molecular interaction, is also discussed. |
format | Text |
id | pubmed-3105500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31055002011-06-02 Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies Tagliamonte, Maria Tornesello, Maria Lina Buonaguro, Franco M Buonaguro, Luigi J Transl Med Review The human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein gp120 presents conserved binding sites for binding to the primary virus receptor CD4 as well as the major HIV chemokine coreceptors, CCR5 and CXCR4. Concerted efforts are underway to understand the specific interactions between gp120 and coreceptors as well as their contribution to the subsequent membrane fusion process. The present review summarizes the current knowledge on this biological aspect, which represents one of the key and essential points of the HIV-host cell interplay and HIV life cycle. The relevance of conformational HIV-1 Envelope proteins presented on Virus-like Particles for appropriate assessment of this molecular interaction, is also discussed. BioMed Central 2011-01-27 /pmc/articles/PMC3105500/ /pubmed/21284899 http://dx.doi.org/10.1186/1479-5876-9-S1-S1 Text en Copyright ©2011 Tagliamonte et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Tagliamonte, Maria Tornesello, Maria Lina Buonaguro, Franco M Buonaguro, Luigi Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title | Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title_full | Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title_fullStr | Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title_full_unstemmed | Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title_short | Conformational HIV-1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies |
title_sort | conformational hiv-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105500/ https://www.ncbi.nlm.nih.gov/pubmed/21284899 http://dx.doi.org/10.1186/1479-5876-9-S1-S1 |
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