Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel belonging to the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily. ABC proteins share a common molecular mechanism that couples ATP binding and hydrolysis at two nucleotide-binding domains (NBDs) to diver...

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Detalles Bibliográficos
Autores principales: Szollosi, Andras, Muallem, Daniella R., Csanády, László, Vergani, Paola
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105517/
https://www.ncbi.nlm.nih.gov/pubmed/21576373
http://dx.doi.org/10.1085/jgp.201110608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105517/
https://www.ncbi.nlm.nih.gov/pubmed/21576373
http://dx.doi.org/10.1085/jgp.201110608

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