A 50% Reduction of Excitability but Not of Intercellular Coupling Affects Conduction Velocity Restitution and Activation Delay in the Mouse Heart

INTRODUCTION: Computer simulations suggest that intercellular coupling is more robust than membrane excitability with regard to changes in and safety of conduction. Clinical studies indicate that SCN5A (excitability) and/or Connexin43 (Cx43, intercellular coupling) expression in heart disease is red...

Descripción completa

Detalles Bibliográficos
Autores principales: Stein, Mèra, van Veen, Toon A. B., Hauer, Richard N. W., de Bakker, Jacques M. T., van Rijen, Harold V. M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106008/
https://www.ncbi.nlm.nih.gov/pubmed/21673812
http://dx.doi.org/10.1371/journal.pone.0020310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106008/
https://www.ncbi.nlm.nih.gov/pubmed/21673812
http://dx.doi.org/10.1371/journal.pone.0020310

Ejemplares similares