Cargando…

Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation

PURPOSE: We analyzed the impact of immediate intravesical mitomycin C instillation after transurethral resection of the bladder (TURB) on tumor recurrence and progression in patients with periodic mitomycin C instillation. MATERIALS AND METHODS: Between June 2000 and June 2006, a retrospective study...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Seok Jin, Chang, Hyuk Soo, Park, Choal Hee, Kim, Chun Il, Kim, Byung Hoon
Formato: Texto
Lenguaje:English
Publicado: The Korean Urological Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106164/
https://www.ncbi.nlm.nih.gov/pubmed/21687391
http://dx.doi.org/10.4111/kju.2011.52.5.323
_version_ 1782204758560342016
author Jung, Seok Jin
Chang, Hyuk Soo
Park, Choal Hee
Kim, Chun Il
Kim, Byung Hoon
author_facet Jung, Seok Jin
Chang, Hyuk Soo
Park, Choal Hee
Kim, Chun Il
Kim, Byung Hoon
author_sort Jung, Seok Jin
collection PubMed
description PURPOSE: We analyzed the impact of immediate intravesical mitomycin C instillation after transurethral resection of the bladder (TURB) on tumor recurrence and progression in patients with periodic mitomycin C instillation. MATERIALS AND METHODS: Between June 2000 and June 2006, a retrospective study was performed in a total of 115 patients with primary bladder tumors receiving a 6-week course of mitomycin C instillation after TURB. The patients were assigned to two groups: 53 patients in the immediate mitomycin C (I-MMC) group were treated by immediate instillation of mitomycin C after TURB and periodic instillation (6 times, 1 time per week), and 62 patients in the MMC group received only periodic instillation. Tumor recurrence and progression were compared in the two groups. RESULTS: During the mean follow-up period of 46.5 months in the I-MMC group and 47.2 months in the MMC group, early recurrence (within 1 year) occurred in 6 of 53 patients (11.3%) in the I-MMC group and in 18 of 62 patients (29.0%) in the MMC group (p<0.02). Although a significantly lower early recurrence rate was observed in the I-MMC group, this difference was not significant for recurrence within 2 or 3 years or for total recurrence. Progression was not significantly different between the two groups regarding the early and total period. CONCLUSIONS: Our study confirmed the positive effect of a single, immediate mitomycin C instillation in patients with non-muscle-invasive bladder tumors who received periodic mitomycin C instillation. This benefit was limited to early recurrence and was not maintained with long-term follow-up. This approach can be an alternative to periodic mitomycin C instillation without immediate instillation.
format Text
id pubmed-3106164
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Korean Urological Association
record_format MEDLINE/PubMed
spelling pubmed-31061642011-06-16 Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation Jung, Seok Jin Chang, Hyuk Soo Park, Choal Hee Kim, Chun Il Kim, Byung Hoon Korean J Urol Original Article PURPOSE: We analyzed the impact of immediate intravesical mitomycin C instillation after transurethral resection of the bladder (TURB) on tumor recurrence and progression in patients with periodic mitomycin C instillation. MATERIALS AND METHODS: Between June 2000 and June 2006, a retrospective study was performed in a total of 115 patients with primary bladder tumors receiving a 6-week course of mitomycin C instillation after TURB. The patients were assigned to two groups: 53 patients in the immediate mitomycin C (I-MMC) group were treated by immediate instillation of mitomycin C after TURB and periodic instillation (6 times, 1 time per week), and 62 patients in the MMC group received only periodic instillation. Tumor recurrence and progression were compared in the two groups. RESULTS: During the mean follow-up period of 46.5 months in the I-MMC group and 47.2 months in the MMC group, early recurrence (within 1 year) occurred in 6 of 53 patients (11.3%) in the I-MMC group and in 18 of 62 patients (29.0%) in the MMC group (p<0.02). Although a significantly lower early recurrence rate was observed in the I-MMC group, this difference was not significant for recurrence within 2 or 3 years or for total recurrence. Progression was not significantly different between the two groups regarding the early and total period. CONCLUSIONS: Our study confirmed the positive effect of a single, immediate mitomycin C instillation in patients with non-muscle-invasive bladder tumors who received periodic mitomycin C instillation. This benefit was limited to early recurrence and was not maintained with long-term follow-up. This approach can be an alternative to periodic mitomycin C instillation without immediate instillation. The Korean Urological Association 2011-05 2011-05-24 /pmc/articles/PMC3106164/ /pubmed/21687391 http://dx.doi.org/10.4111/kju.2011.52.5.323 Text en © The Korean Urological Association, 2011 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Seok Jin
Chang, Hyuk Soo
Park, Choal Hee
Kim, Chun Il
Kim, Byung Hoon
Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title_full Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title_fullStr Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title_full_unstemmed Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title_short Effectiveness of an Immediate Mitomycin C Instillation in Patients with Superficial Bladder Cancer Receiving Periodic Mitomycin C Instillation
title_sort effectiveness of an immediate mitomycin c instillation in patients with superficial bladder cancer receiving periodic mitomycin c instillation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106164/
https://www.ncbi.nlm.nih.gov/pubmed/21687391
http://dx.doi.org/10.4111/kju.2011.52.5.323
work_keys_str_mv AT jungseokjin effectivenessofanimmediatemitomycincinstillationinpatientswithsuperficialbladdercancerreceivingperiodicmitomycincinstillation
AT changhyuksoo effectivenessofanimmediatemitomycincinstillationinpatientswithsuperficialbladdercancerreceivingperiodicmitomycincinstillation
AT parkchoalhee effectivenessofanimmediatemitomycincinstillationinpatientswithsuperficialbladdercancerreceivingperiodicmitomycincinstillation
AT kimchunil effectivenessofanimmediatemitomycincinstillationinpatientswithsuperficialbladdercancerreceivingperiodicmitomycincinstillation
AT kimbyunghoon effectivenessofanimmediatemitomycincinstillationinpatientswithsuperficialbladdercancerreceivingperiodicmitomycincinstillation