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Nuclear Accumulation of Stress Response mRNAs Contributes to the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats

Fragile X–associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder seen in Fragile X premutation carriers. Previous studies found that Fragile X rCGG repeats are sufficient to cause neurodegeneration and that the rCGG repeat-binding proteins Pur α and hnRNP A2/B1 can modulate rCGG–m...

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Detalles Bibliográficos
Autores principales:	Qurashi, Abrar, Li, Wendi, Zhou, Jian-Ying, Peng, Junmin, Jin, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107199/ https://www.ncbi.nlm.nih.gov/pubmed/21655086 http://dx.doi.org/10.1371/journal.pgen.1002102

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