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DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to t...

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Detalles Bibliográficos
Autores principales:	Simsek, Deniz, Brunet, Erika, Wong, Sunnie Yan-Wai, Katyal, Sachin, Gao, Yankun, McKinnon, Peter J., Lou, Jacqueline, Zhang, Lei, Li, James, Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Jasin, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107202/ https://www.ncbi.nlm.nih.gov/pubmed/21655080 http://dx.doi.org/10.1371/journal.pgen.1002080

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