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Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin

Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or elimi...

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Autores principales: Carrai, Maura, Steinke, Verena, Vodicka, Pavel, Pardini, Barbara, Rahner, Nils, Holinski-Feder, Elke, Morak, Monika, Schackert, Hans K., Görgens, Heike, Stemmler, Susanne, Betz, Beate, Kloor, Matthias, Engel, Christoph, Büttner, Reinhard, Naccarati, Alessio, Vodickova, Ludmila, Novotny, Jan, Stein, Angelika, Hemminki, Kari, Propping, Peter, Försti, Asta, Canzian, Federico, Barale, Roberto, Campa, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107225/
https://www.ncbi.nlm.nih.gov/pubmed/21674048
http://dx.doi.org/10.1371/journal.pone.0020464
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author Carrai, Maura
Steinke, Verena
Vodicka, Pavel
Pardini, Barbara
Rahner, Nils
Holinski-Feder, Elke
Morak, Monika
Schackert, Hans K.
Görgens, Heike
Stemmler, Susanne
Betz, Beate
Kloor, Matthias
Engel, Christoph
Büttner, Reinhard
Naccarati, Alessio
Vodickova, Ludmila
Novotny, Jan
Stein, Angelika
Hemminki, Kari
Propping, Peter
Försti, Asta
Canzian, Federico
Barale, Roberto
Campa, Daniele
author_facet Carrai, Maura
Steinke, Verena
Vodicka, Pavel
Pardini, Barbara
Rahner, Nils
Holinski-Feder, Elke
Morak, Monika
Schackert, Hans K.
Görgens, Heike
Stemmler, Susanne
Betz, Beate
Kloor, Matthias
Engel, Christoph
Büttner, Reinhard
Naccarati, Alessio
Vodickova, Ludmila
Novotny, Jan
Stein, Angelika
Hemminki, Kari
Propping, Peter
Försti, Asta
Canzian, Federico
Barale, Roberto
Campa, Daniele
author_sort Carrai, Maura
collection PubMed
description Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99–1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06–1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12–1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.
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spelling pubmed-31072252011-06-13 Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin Carrai, Maura Steinke, Verena Vodicka, Pavel Pardini, Barbara Rahner, Nils Holinski-Feder, Elke Morak, Monika Schackert, Hans K. Görgens, Heike Stemmler, Susanne Betz, Beate Kloor, Matthias Engel, Christoph Büttner, Reinhard Naccarati, Alessio Vodickova, Ludmila Novotny, Jan Stein, Angelika Hemminki, Kari Propping, Peter Försti, Asta Canzian, Federico Barale, Roberto Campa, Daniele PLoS One Research Article Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99–1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06–1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12–1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin. Public Library of Science 2011-06-02 /pmc/articles/PMC3107225/ /pubmed/21674048 http://dx.doi.org/10.1371/journal.pone.0020464 Text en Carrai et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Carrai, Maura
Steinke, Verena
Vodicka, Pavel
Pardini, Barbara
Rahner, Nils
Holinski-Feder, Elke
Morak, Monika
Schackert, Hans K.
Görgens, Heike
Stemmler, Susanne
Betz, Beate
Kloor, Matthias
Engel, Christoph
Büttner, Reinhard
Naccarati, Alessio
Vodickova, Ludmila
Novotny, Jan
Stein, Angelika
Hemminki, Kari
Propping, Peter
Försti, Asta
Canzian, Federico
Barale, Roberto
Campa, Daniele
Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title_full Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title_fullStr Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title_full_unstemmed Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title_short Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin
title_sort association between tas2r38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of caucasian origin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107225/
https://www.ncbi.nlm.nih.gov/pubmed/21674048
http://dx.doi.org/10.1371/journal.pone.0020464
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