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Polarity Changes in the Transmembrane Domain Core of HIV-1 Vpu Inhibits Its Anti-Tetherin Activity

Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. The HIV-1 accessory protein Vpu can efficiently antagonize this restriction. In this study, we analyzed mutations of the transmembrane (TM) domain of Vpu, includin...

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Detalles Bibliográficos
Autores principales:	Lv, Mingyu, Wang, Jiawen, Wang, Xiaodan, Zuo, Tao, Zhu, Yingzi, Kong, Wei, Yu, Xianghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107245/ https://www.ncbi.nlm.nih.gov/pubmed/21674066 http://dx.doi.org/10.1371/journal.pone.0020890

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