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ATR mediates cisplatin resistance in a p53 genotype-specific manner

The protein kinase encoded by the ataxia-telangiectasia and Rad3-related (ATR) gene is activated by DNA damaging agents that are frequently employed as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic dru...

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Detalles Bibliográficos
Autores principales:	Sangster-Guity, N, Conrad, BH, Papadopoulos, N, Bunz, F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107343/ https://www.ncbi.nlm.nih.gov/pubmed/21258400 http://dx.doi.org/10.1038/onc.2010.624

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