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Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy
BACKROUND: Experimental evidence indicates that certain drugs, that are secondary or tertiary amines or amides, form N-nitroso compounds in the presence of nitrite in an acidic environment. Nitrosatable drugs have been associated with birth defects in a few epidemiologic studies. This study describe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107676/ https://www.ncbi.nlm.nih.gov/pubmed/21472845 http://dx.doi.org/10.1002/bdra.20808 |
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author | Brender, Jean D Kelley, Katherine E Werler, Martha M Langlois, Peter H Suarez, Lucina Canfield, Mark A |
author_facet | Brender, Jean D Kelley, Katherine E Werler, Martha M Langlois, Peter H Suarez, Lucina Canfield, Mark A |
author_sort | Brender, Jean D |
collection | PubMed |
description | BACKROUND: Experimental evidence indicates that certain drugs, that are secondary or tertiary amines or amides, form N-nitroso compounds in the presence of nitrite in an acidic environment. Nitrosatable drugs have been associated with birth defects in a few epidemiologic studies. This study describes the prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy and examines maternal factors associated with such use. METHODS: Data were analyzed from the National Birth Defects Prevention Study and included 6807 mothers who gave birth to babies without major congenital malformations during 1997 to 2005. Information was collected by telephone interview about medication use, demographic factors, and maternal health. Drugs taken during the first trimester were classified according to nitrosatability, amine and amide functional groups, and primary indication of use. RESULTS: Approximately 24% of the women took one or more nitrosatable drugs during the first trimester, including 12.4%, 12.2%, and 7.6% who respectively took secondary amines, tertiary amines, or amides. Five of the ten most commonly taken drugs were available over the counter. Women who were non-Hispanic white (29.5%), with 1 year or more college education (27.3%) or 40 years or older (28.8%) had the highest prevalence of use. Supplemental vitamin C, an inhibitor of nitrosation, was not taken by 41.6% and 19.3% of nitrosatable drug users during the first and second months of pregnancy, respectively. CONCLUSIONS: In this U.S. population, ingestion of drugs classified as nitrosatable was common during the first trimester of pregnancy, especially among non-Hispanic white, more educated, and older mothers. Birth Defects Research (Part A) 2011. © 2011 Wiley-Liss, Inc. |
format | Online Article Text |
id | pubmed-3107676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Wiley Subscription Services, Inc., A Wiley Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-31076762011-10-05 Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy Brender, Jean D Kelley, Katherine E Werler, Martha M Langlois, Peter H Suarez, Lucina Canfield, Mark A Birth Defects Res A Clin Mol Teratol Original Article BACKROUND: Experimental evidence indicates that certain drugs, that are secondary or tertiary amines or amides, form N-nitroso compounds in the presence of nitrite in an acidic environment. Nitrosatable drugs have been associated with birth defects in a few epidemiologic studies. This study describes the prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy and examines maternal factors associated with such use. METHODS: Data were analyzed from the National Birth Defects Prevention Study and included 6807 mothers who gave birth to babies without major congenital malformations during 1997 to 2005. Information was collected by telephone interview about medication use, demographic factors, and maternal health. Drugs taken during the first trimester were classified according to nitrosatability, amine and amide functional groups, and primary indication of use. RESULTS: Approximately 24% of the women took one or more nitrosatable drugs during the first trimester, including 12.4%, 12.2%, and 7.6% who respectively took secondary amines, tertiary amines, or amides. Five of the ten most commonly taken drugs were available over the counter. Women who were non-Hispanic white (29.5%), with 1 year or more college education (27.3%) or 40 years or older (28.8%) had the highest prevalence of use. Supplemental vitamin C, an inhibitor of nitrosation, was not taken by 41.6% and 19.3% of nitrosatable drug users during the first and second months of pregnancy, respectively. CONCLUSIONS: In this U.S. population, ingestion of drugs classified as nitrosatable was common during the first trimester of pregnancy, especially among non-Hispanic white, more educated, and older mothers. Birth Defects Research (Part A) 2011. © 2011 Wiley-Liss, Inc. Wiley Subscription Services, Inc., A Wiley Company 2011-04 2011-04-06 /pmc/articles/PMC3107676/ /pubmed/21472845 http://dx.doi.org/10.1002/bdra.20808 Text en Copyright © 2011 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Article Brender, Jean D Kelley, Katherine E Werler, Martha M Langlois, Peter H Suarez, Lucina Canfield, Mark A Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title | Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title_full | Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title_fullStr | Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title_full_unstemmed | Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title_short | Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy |
title_sort | prevalence and patterns of nitrosatable drug use among u.s. women during early pregnancy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107676/ https://www.ncbi.nlm.nih.gov/pubmed/21472845 http://dx.doi.org/10.1002/bdra.20808 |
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