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Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

Lung tissue from COPD patients displays oxidative DNA damage. The present study determined whether oxidative DNA damage was randomly distributed or whether it was localized in specific sequences in either the nuclear or mitochondrial genomes. The DNA damage-specific histone, gamma-H2AX, was detected...

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Detalles Bibliográficos
Autores principales:	Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107697/ https://www.ncbi.nlm.nih.gov/pubmed/21660298 http://dx.doi.org/10.2147/COPD.S15922

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